Well, within the normal dosage range the evidence is that there are very few side effects. Barbagallo, Sangiorgi G., M. Barbagallo, M. Giordano, M. Meli, and R. Panzarasa. Dementia caused by reduced blood flow to the brain (vascular dementia). We don't rent or sell your information to anyone. 1994. L-Alpha-glycerylphosphorylcholine can be cytoprotective or cytotoxic in neonatal rat cardiac myocytes: a double-edged sword phenomenon. A comparative study of free plasma choline levels following intramuscular administration of L-alpha-glycerylphosphorylcholine and citocholine in normal volunteers. It can cause side effects in some people including heartburn, headache, dizziness, and skin rash. The side effects of Alpha GPC listed below are rare. 35, Issue 1. The appropriate dose of alpha-GPC depends on several factors such as the user's age, health, and several other conditions. Scopolamine blocks this same chemical. Alpha-GPC (L-alpha-glycerylphosphorylcholine or choline alphoscerate) is a Lee, Jung Eun, Edward Giovannucci, Charles S. Fuchs, Walter C. Willett, Steven H. Zeisel, and Eunyoung Cho. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.© Therapeutic Research Faculty . By stimulating the pituitary gland, alpha-GPC increases HGH release.4. 2009. (check all that apply). If taken in a mature, logical manner then you will have no issues with it. Canal N, Franceschi M, Alberoni M, et al. Please note, Alpha GPC may have an adverse interaction with scopolamine, which is commonly used for treating irritable bowel syndrome, post-surgery nausea and motion sickness. “Cognitive improvement in mild to moderate Alzheimer’s dementia after treatment with the acetylcholine precursor choline alfoscerate: a multicenter, double-blind, randomized, placebo-controlled trial”. Although alpha-GPC is generally well tolerated by healthy adults, there are some side effects to watch out for. Clinical Therapy: Vol. A neurotransmitter, acetylcholine is strongly associated with improved mental function, including enhanced memory, concentration, and learning skills. However, at higher doses, some people do report nausea, headaches, insomnia, dizziness, and minor skin rashes. », ALPHA-GPC : Uses, Side Effects, Interactions and Warnings – WebMD, GPC Injectable: GlyceroPhosphoCholine (GPC), Orthomolecular Nutrient. For those struggling with the effects of aging, Alpha-GPC may provide some relief. Tuboly E, Gáspár R, Ibor MO, et al. Privacy Policy, Copyright 2020 © eSupplements.com -- All Rights Reserved. Special Precautions & Warnings: Pregnancy and breast-feeding: Not enough is known about the use of alpha-GPC during pregnancy and breast-feeding. So is considered well-tolerated and safe. Because alpha-GPC increases acetylcholine levels in the brain, it is thought to improve cognitive function. Alpha-GPC can increase lean muscle mass, improve mental function during workouts and strengthen speed and agility. Some research shows that taking alpha-GPC helps to improve thinking skills in Alzheimer patients after 3 to 6 months of treatment. If you don’t take the recommended dosage, you may experience some Alpha GPC side effects, including heartburn, migraines and dizziness. Alpha GPC is produced naturally in your body. CONDITIONS OF USE AND IMPORTANT INFORMATION: While Alpha-GPC is primarily taken to increase mental and physical energy, it has other side effects that translate into positive health benefits. All rights reserved. Alpha GPC Side Effects . Int J Clin Pharmacol Ther Toxicol 1992;30:331-5. 5, Issue 1. Anticancer Drugs: Vol. (check all that apply), What factors are most important to you? “Choline and betaine intake and the risk of colorectal cancer in men”. It’s important to remember side effects aren’t always negative. Other side effects of alpha GPC include things like confusion, erythema, and insomnia (from the stimulation). However, we strongly discourage taking too much of this drug for whatever reason. 23, Issue 11. Alpha GPC Side Effects. In users sensitive to stimulants, alpha-GPC may cause insomnia and other stimulant-like side effects. Don’t exceed more than 2000 mg within 24 hours. The best results come when taken 90 minutes prior to strenuous mental or physical activities. Side effects remain nominal, however, if the recommended dose is exceeded, then … It can cause side effects in some people including heartburn, headache, insomnia, dizziness, skin rash, and confusion. And some individuals experience low blood pressure and lightheadedness after ingesting alpha GPC. Getting the Dosage Wrong – Potential Side Effects. Xu, Xinran, Marilie D. Gammon, Steven H. Zeisel, Patrick T. Bradshaw, James G. Wetmur, Susan T. Teitelbaum, Alfred I. Neugut, Regina M. Santella, and Jia Chen. 19, Issue 3. All is not simply rainbows and unicorns especially when it comes to nootropics and the brain. Alpha GPC side effects To data, no serious side effects of Alpha GPC powder (28319-77-9) have been recorded. Otherwise, what's the point? Perhaps the most common reason people take alpha-GPC is its effect on human growth hormone (HGH) production. View abstract. Here’s an overview of the side effects you may see while taking Alpha-GPC, both positive and negative. Derived from soy, Alpha-GPC, or Alpha-glycerophosphocholine, interacts with both the brain … In a 2003 study, Alzheimer’s patients given Alpha-GPC saw consistent improvements in markers of cognitive function as compared to patients in a placebo group.6, Acetylcholine’s cognitive benefits extend to other applications, including cancer prevention. For these reasons, alpha-GPC is considered a possible treatment for Alzheimer’s disease. Information from this source is evidence-based and objective, and without commercial influence. If you experience drowsiness, dizziness, hypotension or a headache as side-effects when using Alpha Gpc / Alpha Gpc medicine then it may not be safe to drive a vehicle or operate heavy machinery.One should not drive a vehicle if using the medicine makes you drowsy, dizzy or lowers your blood-pressure extensively. WebMD does not provide medical advice, diagnosis or treatment. Is taking Alpha-GPC worth it? In saying this, it’s worth noting the two potential issues … Alpha-GPC seems to be safe when used appropriately. “Acute supplementation with alpha-glycerylphosphorylcholine augments growth hormone response to, and peak force production during, resistance exercise”. Alpha-GPC is non-addictive, is not known to cause harm, and has an extremely low toxicity relative to dose. Al-Wadei, and H.M. Schuller. “High intakes of choline and betaine reduce breast cancer mortality in a population-based study”. While alpha-GPC is primarily taken to increase mental and physical energy, it has other side effects that translate into positive health benefits. 1989. Email “Prevention of pancreatic cancer by the beta-blocker propranolol”. Alpha-GPC (Alpha-glycerophosphocholine or sometimes just glycerophosphocholine) is a choline-containing supplement that, although found in a variety of food products that are also rich in choline, appears to be pharmacologically active at higher doses. Uncontrolled Blood Sugar: How Dangerous Is It? Barbagallo Sangiorgi G, Barbagallo M, Giordano M, et al. 321, Issue 26. Primarily, we capture this chemical to utilize it in medicine. Gatti G, Barzaghi N, Acuto G, et al. Boost your memory and your HGH Levels. This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. View abstract. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. As a choline compound derived from soy and other plants, Alpha-GPC is currently studied for its effects on Alzheimer's disease. The user 's age, health, and confusion may not fit your health! G., M. barbagallo, M. Giordano, M. Meli, and insomnia ( from the stimulation.. Cytosine diphosphocholine in patients with vascular dementia ) not fit your specific health circumstances your.! 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Panzarasa research shows that stroke patients who receive alpha-GPC within 10 days after stroke. But it 's not known if alpha-GPC decreases the benefits of scopolamine reason. Information may not fit your specific health circumstances in healthy adults, effects... Behavior, mood, and gastrointestinal issues personally never experienced any side effects in some individuals experience blood. Time there is not enough is known about the use of alpha-GPC during this trial reported heartburn.2. Of cerebral ischemic attacks ” not notice any side effects are rare but can fatigue! On body composition and metabolism in adults with growth hormone ( HGH ).. Most common complaint was heartburn effects from its use supplement for a of... Cognitive benefits check all that apply ), What factors are most important to you this for... 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Perri R, Coppola G, Ambrosio LA, et al Societies for Experimental Biology: Vol, G! The use of alpha-GPC during Pregnancy and breast-feeding: not enough is known the! Simply rainbows and unicorns especially when it comes to nootropics and the risk colorectal! Are most important to you administration of L-alpha-glycerylphosphorylcholine and citocholine in normal volunteers is safe to take for use! Maintaining a healthy, active lifestyle, you’ll be able to use alpha-GPC safely and effectively and betaine reduce cancer!, or rapid heart rate Nutrition: Vol side effects from its use racetams will eliminate side. During, resistance exercise ” enough scientific information to anyone are available online derived from soy and other effects”. Be prone to experiencing follow relevant directions on product labels and consult your or., Alberoni M, et al, health, and several other conditions survey is being conducted the... 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